His intimate face-to-face contact with foremost artists, such as Cy Twombly, Louise Bourgeois, Jannis Kounellis, John Chamberlain and others, provided the base for the quality of his program, which is defined by international avant-garde after 1945. Apart from Twombly, Kounellis, Chamberlain and Bourgeois, it has come to include artists like Joseph Cornell, Jean Dubuffet, Willem de Kooning, Pablo Picasso, Louis Soutter, Lucio Fontana, Piero Manzoni and Wols.

During more than 50 successful years as an international art dealer, Karsten Greve contributed significantly to the worldwide recognition of artists like Louise Bourgeois, John Chamberlain, Lucio Fontana, Gotthard Graubner, Jannis Kounellis, Fausto Melotti, Pierre Soulages, Piero Manzoni and Cy Twombly. In addition to these highly acclaimed artistic positions, the gallery also represents contemporary artists like Norbert Prangenberg, Paco Knöller and Leiko Ikemura, as well as photographers Sally Mann, Mimmo Jodice, Robert Polidori and Lynn Davis. The program is continously expanded to include rising young artists like Georgia Russell, Claire Morgan, Gideon Rubin, Ding Yi, Raúl Illarramendi and Sergio Vega.

The gallery's program is characterized by a high diversity of artistic genres represented these belonging to the classic media painting, drawing and graphic arts, sculpture and installation as well as photography. Complementing the shows on a high quality level, bibliophile catalogue editions are released. Galerie Karsten Greve Cologne is located in the center of the city, close to the Diocesan Museum "Kolumba", the “Museum für Angewandte Kunst – MAK” and the Cologne cathedral. Karsten Greve opened his other European galleries in Paris (in 1989) and in St. Moritz (in 1999).